[Pyr1]-Apelin-13

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

[Pyr1]-Apelin-13 是一种有效的、选择性的内源性 Apelin 受体 (APJ) 激动剂。[Pyr1]-apelin-13 封装在 lipoPEG 颗粒 (lipoPEG-PA13) 中，可在生理条件下实现持续和延长的药物释放。 [Pyr1]-apelin-13 纳米载体在压力过载诱发心力衰竭的小鼠模型中证明了 [Pyr1]-apelin-13 在预防心功能障碍方面具有可持续的长期作用。

[Pyr1]-Apelin-13 is a potent and selective endogenous Apelin receptor (APJ) agonist.[Pyr1]-apelin-13 encapsulation in lipoPEG particles (lipoPEG-PA13) results in sustained and extended drug release under physiological conditions[1].[Pyr1]-apelin-13 nanocarriers in a mouse model of pressure-overload induced heart failure demonstrate a sustainable long-term effect of [Pyr1]-apelin-13 in preventing cardiac dysfunction. [Pyr1] apelin-13 (1, 5 μg) improves locomotor activity and reduces pain symptoms, cavity size and caspase-3 levels in rats. [Pyr1] apelin-13 (1, 5 μg) significantly increases thermal paw withdrawal latency. [Pyr1] apelin-13 in 5 μg dose also produces significant attenuation in paw withdrawal threshold compared to SCI animals from the second week post SCI.

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[pGlu1]-Apelin-13

Others

Other Targets

endogenous apelin receptor

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217082-60-5

1533.8

C69H108N22O16S

>98% (HPLC)

H2O:50 mg/mL (32.60 mM)

CSCCC(NC(=O)C1CCCN1C(=O)CNC(=O)C(CCCCN)NC(=O)C(CC1=CNC=N1)NC(=O)C(CO)NC(=O)C(CC(C)C)NC(=O)C(CCCNC(N)=N)NC(=O)C1CCCN1C(=O)C(CCCNC(N)=N)NC(=O)C1CCC(=O)N1)C(=O)N1CCCC1C(=O)NC(CC1=CC=CC=C1)C(O)=O

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(-20℃)

With Ice Pack

≥ 2 years